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Therapeutic Index

Famexavir TM 250 mg / 500 mg
Each tablet contains:


Composition:

Famciclovir           ........................................................................250 mg

Famciclovir           ........................................................................500 mg

Indications: Herpes Zoster: Famexavir (famciclovir) is indicated for the treatment of acute herpes zoster (shingles), treatment or suppression of recurrent genital herpes in immunocompetent patients, and treatment of recurrent mucocutaneous herpes simplex infections in HIV-infected patients.

Description:
Famciclovir undergoes rapid biotransformation to the active compound, penciclovir, which is phosphorylated by viral thymidine kinase in HSV-1, HSV-2, and VZV-infected cells to a monophosphate form; this is then converted to penciclovir triphosphate and competes with deoxyguanosine triphosphate to inhibit HSV-2 polymerase (eg, herpes viral DNA synthesis/replication is selectively inhibited)

Warnings/Precautions
Has not been established for use in initial episodes of genital herpes, patients with ophthalmic or disseminated zoster, or in immunocompromised patients with herpes zoster. Dosage adjustment is required in patients with renal insufficiency. Tablets contain lactose; do not use with galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption syndromes. Safety and efficacy have not been established in children <18 years of age.

 

Contraindications

Hypersensitivity to famciclovir, penciclovir, or any component of the formulation

 

Dosage and Administration
Adults : Herpes zoster: 250 mg three times daily for 7 days or 750 mg once daily for 7 days (500 mg three times daily for 10 days in immunocompromised). Genital herpes: First episode: 250 mg three times daily for 5 days; recurrent infection, 125 mg twice daily for 5 days (500 mg twice daily for 7 days in all episodes in immunocompromised). Suppression of recurrent genital herpes: 250 mg twice daily (500 mg twice daily in HIV patients) interrupted every 6-12 months. Children: Not recommended
 

Interactions
Uricosurics: probenicid possibly reduces famciclovir excretion thereby increasing plasma concentration

 

Dosage: As per the physician’s advice.

 

Presentations:                   

                                                 MRP        Retailer      Stockist

            10 tablets                 315.00       252.00        226.80

              7 tablets                 280.75       224.60        202.14
 
       
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